地塞米松對實驗性過敏性鼻炎小鼠血清和鼻中隔黏膜TGF-β表達的影響.pdf

1、山西醫(yī)科大學碩士學位論文地塞米松對實驗性過敏性鼻炎小鼠血清和鼻中隔黏膜TGFβ表達的影響姓名：成娜莎申請學位級別：碩士專業(yè)：耳鼻咽喉頭頸外科指導教師：張克軍20100420山兩醫(yī)科大學碩士學位論文AninVestigationontheefkctsofdexamethasoneonTGF—pleVelintheserumandnasalseptalmucosaofmousewithexperimentalallergierhinitis

2、AbstractObjec晰e：ToinVestigatetheeffectsofdex鋤e她sone(DEX)onTGF—pleVelsinthesenlIllandnaSalseptalmucosaofmouse麗thexperinlentala11e唱icrhinitis(EAR)Methods：Fo啊BALB／cmiceweremdomlyassignedt0four印ups，includingnomalcontrolgroup

3、(A)，modelcontrolgroup(B)andtwo仃eatmem伊oups(CarldD)EARmodelwassensitizedwithovalb啪in(OVA)Symptomscore，hematoxylineosinforeosinophilin丘ltration，andiInmunostaillingforTGFpinnasalmucosawereaIlalyzedaSwen弱enz)rmelinkedim瑚unos

4、orbemassay(ELISA)waStakentodetectTGF—pandIgEinsemspss115so腳arew舔usedt0analyzetheempiricaldammI沁sultswereshown越mean士SEUsingaone—wayANOVAforcomp撕sonofcontrolversustrea_tmentT11ethresholdforsigIlificance、懈PO05)111ereisnoTGF

5、—pexpressioninnasalseptalmucosaofAgroup，butitiseVidentinBgroupTheexpressionofTGFpinnasalseptalmuCosainbothtrIjatment莎oupsarelowerthaIlgroupB(PO01)Conclusion：ThisstlJdysuggeststhatDEXcaIlir山ibitthedi疵rentinductionofrmalal

6、le瑪yaccordingtothetimeofitsadminis拄ation。DEXwhenadminiSteredbeforegeneralsenSi_ti撕?，攕uppressesearlyandlateallergicreactioIlsDEXadmillimationbeforelocalchallengeinsensitiZedmicecallomysuppresslatealle唱icreactionsDEXmaypla

7、yall婦porrtantrolethrou曲atleasttwokindsofmech砌smsi11innuencingtheexpressionofTGFpinthecourseoftrea：tmentofalle畫crhinitisOnekindbyincreasingtllethesemmleVelofTGF—ptosupprcssalle畫creaction，a11dtheotherkindthrou曲theinllibiti